California, US residents click here (https://www.unither.com/docs/UNITHER%20Applicant%20Notice%20-%20%2812-22-23%29%20Final%202.15.24%20Combined%20EN%20and%20French.pdf#page=9) .

The job details are as follows:

What We Do

At United Therapeutics, we build on the strength of our research and development expertise and a distinctive, entrepreneurial culture that encourages diversity, innovation, creativity, sustainability, and, simply, fun. Since inception, our mission has been to find a cure for pulmonary arterial hypertension and other life-threatening diseases. Toward this goal we have successfully gained FDA approval for five medicines, we are always conducting new clinical trials, and we are working to create an unlimited supply of manufactured organs for transplantation.

We are the first publicly-traded biotech or pharmaceutical company to take the form of a public benefit corporation (PBC). Our public benefit purpose is to provide a brighter future for patients through (a) the development of novel pharmaceutical therapies; and (b) technologies that expand the availability of transplantable organs. At the same time, we seek to provide our shareholders with superior financial performance and our communities with earth-sensitive energy utilization.

Our company was founded by an entrepreneur whose daughter was diagnosed with a life-threatening condition. She sought to find treatment options and a cure for her daughter and patients like her. We are founder-led, and relentless in our pursuit of “medicines for life”. We continue to research and develop treatments for cardiovascular and pulmonary diseases, and other orphan diseases.

The selected Co-op will need to be onsite at the RTP, North Carolina office for the entire duration of this co-op, starting the Fall of 2024. United Therapeutics does not provide housing or transportation. A stipend for relocation assistance may be provided on a case-by-case basis.

How you’ll contribute

The Fall 2024 co-op will assist in research & development efforts to develop novel cell- and tissue-based products for treating pulmonary hypertension and other lung diseases. You will complete a focused research project during this time. This will involve generating data that addresses an outstanding question, drawing conclusions, and writing reports to document the outcomes of experiments. You will present data to management, team leaders, and research staff during internal review meetings and make a final presentation of project findings.

Minimum requirements to apply

• Candidates are expected to be actively enrolled in an educational program toward the completion of a Master’s Degree or PhD in biology, biomedical sciences, biomedical engineering, or related field.

• Must be available to work 40 hours/week onsite in the RTP, NC facility

• Relevant technical laboratory experience

• Experience leading independent research project of at least 6 months (i.e. designing experiments, testing hypotheses, interpreting results in the context of literature)

Expectations and qualities of a successful candidate:

• Motivated, curious, hard-working, able to think creatively, and/or able to learn quickly

• Ability to work independently and develop scientific strategies

• Ability to independently follow experimental methods and protocols

• Ability to troubleshoot key issues and improve experimental strategies

• Ability to initiate and manage day-to-day tasks effectively

• Ability to organize and present data

• Excellent team skills; must work well with others

• Excellent written and verbal communication skills

Project Overview

The project can be tailored to the applicant’s research background but will generally involve investigation of the following areas:

• Investigating the migration/invasion of endothelial cells into confined spaces in decellularized lung scaffold microvasculature using 2D and 3D culture models

• Providing insight into endothelial cell behavior in lung scaffolds (migration, metabolism, barrier, etc.) using gene and protein analyses

• Screening compounds and developing strategies to improve cell migration/invasion into confined spaces of lung scaffold microvasculature, especially capillaries

Preferred Skillsets

• Specific experience or training:

• Knowledge of vascular biology and/or endothelial cell behavior (migration, mechanotransduction, barrier formation, angiogenesis, etc.)

• Experience with mammalian cell culture (preferably endothelial cells) and aseptic technique in an academic and/or industrial applied laboratory setting

• Experience with analytical assays to cells in culture and/or tissue (e.g. Western blot, proteome profiling and/or LegendPlex kits, Nanostring, qPCR, etc.)

• Experience with 3D cell culture systems (e.g. hydrogels, systems to apply shear stress/flow to cells, or microfluidic chips)

• Ideal but not required : Familiarity with analyzing large gene and/or protein datasets

• Additional skills:

• Microsoft Office (Excel, Powerpoint, Word, OneNote)

• Data analysis programs (e.g. Graphpad Prism, MATLAB, Rosalind, nSolver)

• Image analysis tools (e.g. FIJI/ImageJ, Imaris)

• Ideal but not required : Coding languages (e.g. Python, C++, R) in the context of gene/protein data analysis

While United Therapeutics does not require vaccination for Covid-19 at this time, we strongly encourage all employees and visitors to remain up to date on vaccinations and boosters to protect one another from illness. Employees working in customer-facing roles must adhere and comply with customers’ credentialing guidelines, which may require vaccination against Covid -19, the influenza virus, and other illnesses that could be harmful to healthcare staff and patients.

United Therapeutics Corporation is an Equal Opportunity/Affirmative Action Employer - EOE Minorities / Females / Protected Veterans / Individuals with Disabilities

We strive to be an organization that engages the minds, hearts, and most spirited efforts of each of our employees. Our sense of purpose transforms what we do from work into mission, occupation into vocation and achievement into success.

We challenge our employees with innovative and revolutionary projects, offer an environment which fosters high-level job performance and provide a highly competitive total rewards package. This is what makes United Therapeutics a stimulating place to work.