University of Pennsylvania Manufacturing Associate 3, Pre-clinical Vector in Philadelphia, Pennsylvania
The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn’s distinctive interdisciplinary approach to scholarship and learning.
Penn offers a unique working environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide variety of atmospheres, Philadelphia is the perfect place to call home for work and play.
The University offers a competitive benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and resources, and much more.
Posted Job Title
Manufacturing Associate 3, Pre-clinical Vector
Job Profile Title
Resource Technologist B
Job Description Summary
The Gene Therapy Program (GTP) is entering a new era of unprecedented opportunity with great potential to reshape the face of medicine as we know it. Our discoveries have set the stage for successful treatments and possibly even cures for devastating genetic diseases.
The laboratory of Dr. Jim Wilson, at GTP of the University of Pennsylvania, has been a leader in the development of innovative vector technology for close to three decades. We have emerged as the “go-to” organization for public and private partners, who want to participate in the gene therapy space. Currently, we are positioned to lead another round of vector innovation and establish pre-clinical and clinical proof-of-concept in therapeutic applications of in-vivo genome editing.
Our Vector Core is a state-of-the-art facility which provides vector-related materials and services in support of basic and translational research worldwide, producing vectors in support of IND-enabling research, conduct GLP assays, oversee CMO's in vector production and is expanding to conduct state-of-the-art process development.
Due to significant growth, the Vector Core is looking for a new, Manufacturing Associate 3, to support the manufacturing and purification efforts of viral vectors.
As a Manufacturing Associate 3, as you begin to emerge as a subject matter expert in upstream or downstream processes, you will be responsible for the production and purification of viral vectors for pre-clinical, IND-enabling Pharmacology and Toxicology studies. You will be documenting your activities on production or batch record forms for QA review. You will clean and sterilize the processing equipment. You will develop proficiency with the processing/purification equipment and be able to troubleshoot issues, perform routine preventative maintenance activities and calibrations. You will also be making suggestions to leadership on updates or corrections that need to be made to any protocols or standard operating procedures.
You will work both independently and as part of a team to accomplish project goals within specified timelines. Successful candidates will have familiarity with aseptic techniques and mammalian cell culture. You will continue to develop skills in upstream and downstream biologics manufacturing, tissue culture, column chromatography, and other purification processes.
BS degree in chemistry, biology, Bio/chemical Engineering or related disciplines with 3 to 5 years or equivalent combination or education and experience
Must have experience with Aseptic Techniques and mammalian cell culture
Experience with tangential flow filtration and column chromatography helpful but not required
Must be meticulous, detail oriented, and analytical
Must be highly motivated, have excellent organizational, communication and interpersonal skills.
Must be able to work independently and as part of a multi-disciplinary team.
Job Location - City, State
Department / School
Perelman School of Medicine
$42,953.00 - $77,315.00
Affirmative Action Statement Penn adheres to a policy that prohibits discrimination on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status, or any other legally protected class.
Special Requirements Background check required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.
The University of Pennsylvania's special character is reflected in the diversity of the Penn community. We seek talented faculty and staff who will constitute a vibrant community that draws on the strength that comes with a substantive institutional commitment to diversity along dimensions of race, ethnicity, gender, sexual orientation, age, religion, disability, veteran status, interests, perspectives, and socioeconomic status. Grounded in equal opportunity, nondiscrimination, and affirmative action, Penn's robust commitment to diversity is fundamental to the University's mission of advancing knowledge, educating leaders for all sectors of society, and public service. The University of Pennsylvania prohibits unlawful discrimination based on race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status, or any other legally protected class.
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